脂肪乳非营养作用在中毒救治中的应用研究进展
Research progress on the application of non-nutritional effects of fat emulsion in the treatment of poisoning
董建光 1林国东 2邱泽武3
作者信息
- 1. 天津市中心妇产科医院重症医学科,天津 300100
- 2. 中国人民解放军南部战区总医院重症医学科,广州 510010;中国人民解放军总医院第五医学中心化学损伤救治科,北京 100071
- 3. 中国人民解放军总医院第五医学中心化学损伤救治科,北京 100071
- 折叠
摘要
脂肪乳是临床上常用于重症患者肠外营养支持治疗的药物.随着医药事业的发展,脂肪乳已形成了多种不同配方的制剂,其中不同类型的脂肪乳有各自代谢和体内供能的特征,应用适应症也有所不同.除提供营养物质的供应外,脂肪乳在免疫调节、抗炎、抗休克、中毒支持治疗、心肺复苏等方面的作用不断被研究.本文对现有的循证医学证据进行梳理,阐述脂肪乳在中毒危重症患者救治过程中发挥非营养功能的机制及治疗作用,对其在救治中毒危重患者中的价值进行探讨,并为今后脂肪乳非营养功能的应用提供部分参考.
Abstract
Fat emulsion is a drug commonly used clinically for parenteral nutrition support in critically ill patients.With the development of the pharmaceutical industry,fat emulsion has formed a variety of different formulations,among which different types of fat emulsion have their own metabolic and body energy supply characteristics,and the application indications are also different.In addition to providing the supply of nutrients,the role of fat emulsion in anti-toxicity,immune regulation,anti-inflammatory,anti-shock,cardiopulmonary resuscitation and other aspects has gradually been discovered.This article reviews the existing evidence-based medical evidence and expounds the mechanism and therapeutic role of fat emulsion in the treatment of critically ill patients with poisoning.Its value in the treatment of critically ill patients with poisoning was discussed,and some references were provided for the application of non-nutritional functions of fat emulsion in the future.
关键词
脂肪乳/中毒/危重症/营养/休克Key words
Fat emulsion/Poisoning/Critical illness/Nourishment/Shock引用本文复制引用
基金项目
天津市医学重点学科(专科)建设项目(TJYXZDXK-043A)
出版年
2024
NETL
NSTL
维普
万方数据