金属污染物通过星形胶质细胞诱发神经毒性的研究进展
Research progress on neurotoxicity induced by metal pollutants through astrocytes
张子阳 1赵新元 1吴启运1
作者信息
- 1. 南通大学公共卫生学院职业医学与环境毒理学系,南通市环境毒理学重点实验室,南通 226019
- 折叠
摘要
自然环境和工业环境中的金属污染物可以通过呼吸道和消化道等途径进入生物体,引起不良健康效应,已有很多文献证实金属污染物具有神经毒性.近些年的研究表明,星形胶质细胞在金属污染物诱发的神经毒性反应中发挥着重要作用.本文概述了近期国内外有关铅、汞、镉、锑、铜等金属物质通过星形胶质细胞引发神经毒性的最新进展,为金属污染物的神经毒性研究提供新的线索.
Abstract
Metal pollutants in the natural environment and industrial environment can enter organisms through the respiratory tract and digestive tract causing adverse health effects.Many kinds of literatures confirm that metal pollutants have neurotoxicity.Recent studies have showed that astrocytes play an important role in neurotoxicity induced by metal pollutants.In this review,the latest progress of neurotoxicity induced by lead,mercury,cadmium,antimony and copper through astrocytes in recent years is summarized,which provides a new clue for the neurotoxicity research of metal pollutants.
关键词
金属/污染物/星形胶质细胞/神经毒性/机制Key words
Metal/Pollutants/Astrocytes/Neurotoxicity/Mechanism引用本文复制引用
基金项目
国家自然科学基金面上项目(82173482)
国家重点研发计划(2019FY101103)
出版年
2024