摘要
目的 探索恶性间皮瘤患者临床病理学特征、治疗方案与预后的关系,为恶性间皮瘤防治提供理论依据.方法 于2022年11月,回顾性分析青岛市中心医院2014年7月至2022年11月确诊的37例恶性间皮瘤患者的临床资料,采用Kaplan-Meier和log-rank检验分析预后影响因素.结果 37例患者的中位年龄为66岁,均经病理学确诊,所有患者的中位生存时间为30.00月.治疗后1、2、3和5年的累积生存率分别为 70.27％(26/37)、48.65％(18/37)、16.22％(6/37)和 13.51％(5/37).姑息治疗组患者中位生存期5.00月,明显低于单纯手术组(30.33月)、化疗组(30.00月)、手术联合化疗组(30.00月)和化疗联合贝伐珠单抗靶向治疗组(47.42月)(P＜0.05).性别、年龄(≥60岁或＜60岁)、吸烟史、职业暴露史、发病部位、手术史均不是恶性间皮瘤患者生存期的影响因素(P＞0.05).结论 恶性间皮瘤临床症状缺乏特异性,但尽早开始治疗仍可延长生存期,而且化疗联合抗血管靶向治疗显示出更好的治疗效果.
Abstract
Objective To explore the relationship between clinicopathological features,treatment and prognosis of patients with malignant mesothelioma,and provide theoretical basis for the prevention and treatment of malignant mesothelioma.Methods In November 2022,the clinical data of 37 patients with malignant mesothelioma diagnosed in Qingdao Central Hospital from July 2014 to November 2022 were retrospectively analyzed,and the prognostic factors were analyzed by Kaplan-Meier and log-rank tests.Results The median age of the 37 patients was 66 years old,all patients were confirmed by pathology.The median survival time of all patients was 30.00 months.The 1-year,2-year,3-year and 5-year cumulative survival rates were 70.27％(26/37),48.65％(18/37),16.22％(6/37)and 13.51％(5/37),respectively.Compared with different treatments,the median survival time of palliative care patients was 5.00 months,which was significantly lower than that of operation group(30.33 months),chemotherapy group(30.00 months),surgery combined with chemotherapy group(30.00 months)and chemotherapy combined with bevacizumab targeted therapy group(47.42 months)(P＜0.05).Gender,age(≥60 years old or＜60 years old),smoking history,occupational exposure history,disease site,and surgical history were not factors affecting the survival of malignant mesothelioma patients(P＞0.05).Conclusion The clinical symptoms of malignant mesothelioma are not specific,but early initiation of treatment can still prolong survival,and chemotherapy combined with anti-vascular targeted therapy shows better therapeutic effect.
NETL
NSTL
万方数据