呼伦贝尔市129例急慢性职业性布鲁氏菌病临床特征分析
Analysis of clinical characteristics of 129 acute and chronic occupational brucellosis in HulunBuir City
梁晨 1魏伟2
作者信息
- 1. 呼伦贝尔市人民医院布鲁氏菌病科,呼伦贝尔 021008
- 2. 呼伦贝尔市疾病预防控制中心职业卫生科,呼伦贝尔 021008
- 折叠
摘要
目的 分析急慢性职业性布鲁菌病患者的流行病学特征和临床资料,为防治职业性布鲁氏菌病提供科学依据.方法 于2022年10月,收集2016年1月至2021年12月呼伦贝尔市疾病预防控制中心进行职业病诊断的129例职业性布鲁氏菌病患者为研究对象,采用x2检验、t检验等对比分析急性期和慢性期患者的流行病学特点、临床特征和实验室检查等资料.结果 职业性布鲁氏菌病急性期患者男性38人、女性4人,年龄为(36.6±8.4)岁;慢性期患者男性73人、女性14人,年龄为(38.4±7.9)岁,二组性别和年龄差异均无统计学意义(P＞0.05).患者职业接触史明确,其中急性期兽医(21例,50.0％)占比明显高于慢性期(25例,28.7％),差异有统计学意义(P＜0.05).职业性布鲁氏菌病急性期患者出现发热、食欲减退症状较慢性期明显增多,出现乏力、关节肌肉疼痛症状明显低于慢性期,差异亦有统计学意义(P＜0.05).急性期患者谷丙转氨酶、谷草转氨酶、C反应蛋白、红细胞沉降率升高和血培养阳性率明显高于慢性期患者,差异均有统计学意义(P＜0.05).结论 职业性布鲁氏菌病患者以中年男性为主,急性期以发热、食欲减退以及炎性指标、肝酶升高为主,慢性期以乏力、关节肌肉疼痛症状多见.布鲁氏菌相关职业暴露人群出现上述不适症状时要尽早就医,及时发现和治疗职业病.
Abstract
Objective To analyze the epidemiological characteristics and clinical data of acute and chronic occupational brucellosis patients in order to provide a scientific basis for the prevention and treatment of occupational brucellosis.Methods In October 2022,a study was conducted on 129 patients diagnosed with occupational brucellosis by HulunBuir Center for Disease Control and Prevention from January 2016 to December 2021.The epidemiological characteristics,clinical features,and laboratory test results of patients in the acute and chronic phases were compared and analyzed using chi-square test and student's t test.Results The acute phase patients included 38 men and 4 women with an average age of(36.6±8.4)years old;the chronic phase patients included 73 men and 14 women with an average age of(38.4±7.9)years old.There were no significant differences in gender and age between the two groups(P＞0.05).The patients had a clear history of occupational exposure,and the proportion of veterinarians in acute stage(21 cases,50.0％)was significantly higher than that in chronic stage(25 cases,28.7％),the difference was statistically significant(P＜0.05).The symptoms of fever and loss of appetite in acute phase of occupational brucellosis were significantly higher than those in chronic phase,and the symptoms of fatigue and joint muscle pain were significantly lower than those in chronic phase,with statistical significances(P＜0.05).The increase of alanine aminotransferase,aspartate aminotransferase,C-reactive protein,erythrocyte sedimentation rate and positive rate of blood culture in acute stage were significantly higher than those in chronic stage,with statistical significances(P＜0.05).Conclusion Occupational brucellosis patients are predominantly middle-aged men,the acute phase is characterized by fever,loss of appetite,and increased inflammatory indicators and liver enzymes,while the chronic phase is characterized by symptoms such as fatigue and joint muscle pain.Brucellosis related occupational exposure population should seek medical treatment as soon as possible when the above symptoms occur,timely detection and treatment of occupational diseases.
关键词
职业病/布鲁氏菌病/临床特征/传染病Key words
Occupational diseases/Brucellosis/Clinical characteristics/Communicable diseases引用本文复制引用
基金项目
内蒙古自治区自然科学基金面上项目(2019MS08182)
国家自然科学基金地区科学基金(82160632)
出版年
2024
NETL
NSTL
万方数据