Chlorfenapyr is a kind of insecticide widely used in agriculture.Acute chlorfenapyr poisoning has a high mortality rate and there is no effective treatment at present.Poisoning caused by oral chlorfenapyr can lead to multiple organs damage such as heart,brain,muscle and retina.Clinical treatment should remove toxicants from the body early to improve the prognosis.In this paper,the death data of 3 patients with chlorfenapyr poisoning were reported and literature search was conducted to discuss the mechanism and treatment of chlorfenapyr poisoning.