This paper reports two cases of occupational severe toxic encephalopathy caused by inhaling excessive nitrogen in an accident.The main reasons are failure to performing field-work standards of limited space operation and emergency rescue.Hypoxia asphyxia is the main pathogenic link of nitrogen toxicity,which can cause brain edema.At the same time,hypoxia can lead to the destruction of intracellular calcium environment,exacerbating ischemia and hypoxia.Clinical case data shows that 2 cases presented with clinical manifestations mainly including coma,high limb muscle tone,and neurological damage,but also cause different degrees of lung,myocardium,liver and kidney damage.Early treatments,hyperbaric oxygen therapy,active prevention and treatment of brain edema,correction of acidosis,maintenance of water and electrolyte balance,anti-infection and corresponding symptomatic support therapy are key treatments.
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