Objective To study the effect of isokinetic training on knee extensor and flexor with nerve function abnormality caused by partial denervation or hemiplegia.Methods Both knees of 16 cases with nerve function abnormality and 16 cases with traumatic osteoarthropathy were evaluated by Cybex 300(60°/s) before and after isokinetic training.The angular velocity began at 60°/s,90°/s,120°/s,150°/s to 180°/s,from here the velocity was gradually descended to 60°/s.Each speed repeated 10 times.Before and after training,peak torque-flexor(PT-F),peak torque-extensor(PT-E),F/Q ratio and difference in % of involved knees were recorded.The change rate of mean muscle strength per week was calculated.The design method was repeatedly measured using analysis of variance to compare the difference in both groups.Results After training:1.The PT-F and PT-E were enhanced.The change rate of PT-F and PT-E in involved knees per week was greater than that of uninvolved knees,but that of abnormal nerve group was obviously lower than that of the control group(PT-F:F=8.82,P<0.01;PT-E:F=4.99,P<0.05).2.The difference in % of PT-F and PT-E in involved knees all was decreased,the reducing amplitude in abnormal nerve group was respectively 3.7% and 4.4% vs. the 11.0% and 13.4% of control group.The difference in % of PT-F and PT-E in control group after training was markedly lower than before(PT-F:F=6.40,P<0.01;PT-E:F=22.69,P<0.01).3.F/Q ratio all was significantly decreased in two groups,but there wasn't obvious difference(F=0.95,P>0.05).Conclusion The study suggests that isokinetic training can improve the muscle strength of nerve function abnormality and stabilize the knee joints in partial denervation and hemiplegia.