全身免疫炎症指数与穿支动脉粥样硬化病患者神经功能恶化的相关性
Correlation between SⅡ and early neurological deterioration in patients with branch atheromatous disease
干德彪 1李军涛 2刘冰 2段军燕 2张博 2贾宗翰 1霍会永2
作者信息
- 1. 067000 承德医学院研究生院
- 2. 邯郸市中心医院神经内科
- 折叠
摘要
目的 探讨入院时全身系统性免疫炎症指数(systemic immune-inflammation index,SⅡ)与穿支动脉粥样硬化病(branch atheromatous disease,BAD)患者发生早期神经功能恶化(early neurological deterioration,END)的相关性.方法 回顾性选取2021年10月至2024年2月邯郸市中心医院神经内科诊治的BAD患者326例,根据是否发生END分为END组97例和非END组229例.比较2组一般临床资料,采用多因素logistic回归分析BAD患者发生END的危险因素,采用ROC曲线分析入院美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、高敏 C 反应蛋白(high sensitivity C-reactive protein,hs-CRP)、SⅡ 对 BAD 患者发生END的预测价值.结果 END组年龄、入院NIHSS评分、hs-CRP、中性粒细胞、SⅡ显著高于非END组,血小板计数、淋巴细胞计数显著低于非END组,差异有统计学意义(P＜0.05,P＜0.01).多因素logistic回归分析显示,入院 NIHSS 评分(OR=1.134,95％CI:1.050～1.226,P=0.001)、hs-CRP(OR=1.131,95％CI:1.024～1.249,P=0.015)、SⅡ(OR=1.001,95％CI:1.001～1.002,P=0.003)为 BAD 患者发生 END 的独立危险因素.SⅡ 预测 BAD患者发生END的曲线下面积为0.660,显著优于入院NIHSS评分和hs-CRP(P＜0.05).结论 炎症指数SⅡ是BAD患者发生END独立危险因素,入院时SⅡ对BAD患者发生END有一定的预测价值.
Abstract
Objective To explore the relationship between systemic immune-inflammation index(SⅡ)at admission and occurrence of early neurological deterioration(END)in patients with branch atheromatous disease(BAD).Methods A retrospective analysis was performed on 326 BAD patients admitted in Department of Neurology of Handan Central Hospital from October 2021 to February 2024.Based on occurrence of END or not,they were divided into END group(97 cases)and non-END group(229 cases).Clinical data of the patients were collected,and multivari-ate logistic regression analysis was used to identify the END risk variables in BAD patients.ROC curve was plotted to evaluate the value of NIHSS score,hs-CRP and SⅡ in predicting the inci-dence of END in the patients.Results Significantly advanced age,higher NIHSS score at admis-sion,and elevated hs-CRP level,neutrophil count and SⅡ,but lower platelet and lymphocyte counts were observed in the END group than the non-END group(P＜0.05,P＜0.01).Multi vari-ate logistic regression analysis indicated that NIHSS score at admission(OR=1.134,95％CI:1.050-1.226,P=0.001),hs-CRP(OR=1.131,95％CI:1.024-1.249,P=0.015),and SⅡ(OR=1.001,95％CI:1.001-1.002,P=0.003)were independent risk factors for END in BAD patients.The AUC value of SⅡ in the prediction of END was 0.660,which was significantly higher than that of NIHSS score and hs-CRP in BAD patients(P＜0.05).Conclusion SⅡ is an independent risk factor for END in BAD patients,and SⅡ at admission has a certain predictive value for the oc-currence of END in these patients.
关键词
动脉粥样硬化/系统性免疫炎症指数/神经功能恶化/穿支动脉粥样硬化病Key words
atherosclerosis/systemic immune-inflammation index/neurological deterioration/branch atheromatous disease引用本文复制引用
出版年
2025
NETL
NSTL
万方数据