非高密度脂蛋白胆固醇与脑小血管病影像总负荷的相关性研究
Collation between non-high density lipoprotein cholesterol and total MRI burden in CSVD patients
周祁惠 1杨磊 1胡文立1
作者信息
- 1. 100020 首都医科大学附属北京朝阳医院神经内科
- 折叠
摘要
目的 探究脑小血管病(cerebral small vessel disease,CSVD)患者非高密度脂蛋白胆固醇(non-high density lipoprotein cholesterol,non-HDL-C)及其与CSVD影像总负荷的关系.方法 选取2021年1月至2024年7月首都医科大学附属北京朝阳医院神经内科收治的年龄≥60岁住院患者303例,根据CSVD影像总负荷评分为0分组108例,1分组61例,2分组66例,3分组35例,≥4分组33例.采用二元logistic回归分析non-HDL-C与CSVD相关性.结果 0分组、1分组、2分组、3分组及≥4分组的TC、non-HDL-C水平逐渐明显升高(P＜0.01).3分组non-HDL-C水平明显高于0分组(P=0.001).2分组、3分组及≥4分组non-HDL-C水平明显高于1分组(P＜0.05).CSVD影像总负荷与non-HDL-C水平呈正相关(P=0.001).对患者年龄、性别、高血压、糖尿病、高脂血症等指标校正后发现,non-HDL-C仍是CSVD的独立危险因素(OR=2.869,95％CI:1.012～8.136,P=0.047).结论 在老年人群中,non-HDL-C升高与CSVD影像总负荷增加密切相关,可作为CSVD的早期干预的指标.
Abstract
Objective To explore the association between non-high density lipoprotein cholesterol(non-HDL-C)and total MRI burden in cerebral small vessel disease(CSVD)patients.Methods A total of 303 inpatients(≥60 years old)admitted in our department from January 2021 to July 2024 were recruited,and divided into 0-burden score group(108 cases),1-burden score group(61 cases),2-burden score group(66 cases),3-burden score group(35 cases),and≥4-burden score group(33 cases)according to the total CSVD burden.The association between non-HDL-C and to-tal MRI burden was analyzed by binary logistic regression analysis.Results The levels of TC and non-HDL-C were gradually increased with increment of 0-MRI burden score in the 0-,1-,2-,3-and ≥4-burden score groups in turn(P＜0.01).The non-HDL-C level was significantly higher in the 3-than the 0-burden score group(P=0.001),and in the 2-,3-and ≥4-than the 1-burden score group(P＜0.05).The total CSVD MRI burden was positively correlated with the non-HDL-C level(P=0.001).After adjustment of confounding factors such as age,gender,hypertension,dia-betes and hyperlipidemia,non-HDL-C was still an independent risk factor for CSVD(OR=2.869,95％CI:1.012-8.136,P=0.047).Conclusion Higher non-HDL-C is strongly associated with in-creased total CSVD MRI burden in the elderly,and it can serve as an early intervention indicator for CSVD.
关键词
大脑小血管疾病/磁共振成像/非高密度脂蛋白胆固醇/影像总负荷Key words
cerebral small vessel diseases/magnetic resonance imaging/non-high density lipopro-tein cholesterol/total MRI burden引用本文复制引用
出版年
2025
NETL
NSTL
万方数据