Syncytial giant cells(SGCs)are epithelial giant cells with multiple uniform and similar nuclei.Clear cell renal cell carcinoma(ccRCC)with SGCs is a rare microscopic morphology.A 70-year-old man was admitted to hospital with multiple nodules in both lungs found by chest CT examination 2 weeks before.A left renal carcinoma with lung metastasis was considered by PET-CT.Cytoreductive nephrectomy was performed,and postoperative pathological diagnosis confirmed ccRCC with SGCs of the left renal.Combined immunotherapy and targeted therapies were administered.There was no disease progression during follow-up period of 28 months.
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