Exosomes are extracellular vesicles derived from the bilayer membrane structure of the cell.It has been reported that the contents of some miRNA,mRNA,lncRNA and protein in exosomes are different between renal cell carcinoma patients and healthy controls,and the differences are statistically significant.These substances in renal cell carcinoma exosomes may be helpful for the diagnosis of renal cell carcinoma which may improve the early diagnosis rate of renal cancer.This article reviews the research progress of exosomes in the diagnosis of renal cell carcinoma.