A case of secondary Burkitt lymphoma of prostate was reported.A 39-year-old patient was admitted to the hospital with no apparent cause for impaired urination with frequent/urgent urination.CT scan of the whole abdomen showed irregular soft tissue mass of the prostate,involving the bladder and rectum,and mild obstructive hydronephrosis of the renal pelvis and ureter.Biopsy of the prostatic mass was performed,and the pathological findings were consistent with Burkitt lymphoma.PET-CT examination showed multiple lesions and lymph node enlargement throughout the body,secondary prostate lymphoma was diagnosed.After diagnosis,the patient was treated with R-DA-EPOCH chemotherapy and followed up for 9 months.Prostate lymphoma is rare and needs to be combined with clinical manifestations and laboratory tests to determine whether it is primary or secondary,but also to distinguish from prostate diseases such as prostatitis and poorly differentiated prostate cancer.