The clinical data of 6 patients with renal angiomyolipoma who underwent off-clamp laparoscopic Thulium laser enucleation in our hospital were retrospectively collected.The average age was(48.5±11.1)years old and the tumor diameter was(4.6±1.7)cm.The R.E.N.A.L.scores were between 4 to 7.All patients successfully completed the off-clamp operation.The average operation time was(150.7±58.1)min,with a blood loss of(48.3±29.3)ml.There were no severe complications such as bleeding,infection and urine leakage,and no significant decline in renal function.During 4 to 26 months of follow-up,no tumor recurrence was observed.Off-clamp laparoscopic Thulium laser enucleation for renal angiomyolipoma is safe and feasible,with less intraoperative bleeding,and has the advantage of protecting renal function.