Clinical cases of necrotizing fasciitis and complete urethral defects in the scrotal region are rare.The diagnosis and treatment are very challenging.This article reports one case.The patient was admitted to the hospital after 1 week of poor urination and 2 days of scrotal swelling,and then underwent bladder diversion,surgical debridement,vacuum-sealing drainage,and wound closure.After four weeks,the wound healed and the patient was discharged.Six months later after surgery,scrotal urethral reconstruction was performed using a circular phimosis pedicled skin flap graft to repair the 12 cm urethral defect.The urethral catheter was removed after three weeks.The bladder fistula tube was removed after 5 weeks.During the follow-up of one year,there was no occurrence of urinary fistula and urinary obstruction.