Sjogren's syndrome is a chronic inflammatory autoimmune disease characterized by invasion of exocrine glands such as lacrimal gland and salivary gland and high lymphocyte infiltration.Interstitial cystitis is a chronic cystitis disease with frequent micturition,urgency,nocturia and/or pelvic pain as its main clinical manifestations,and its pathological changes are bladder submucosal ulcer and fibrosis as its main manifestations.Sjogren's syndrome complicated with interstitial cystitis is not uncommon.Anti-muscarinic type 3 acetylcholine receptor(M3R)antibody will not only cause gland dysfunction,but also play an important role in the pathogenesis of interstitial cystitis.The pathogenesis may include:① Immune inflammation accompanied by mast cells and neurogenic inflammation with up-regulation of bladder sensory nerve.②The detrusor contraction function is impaired,which induces ATP release and stimulates sensory nerve outflow.
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