A retrospective analysis was conducted on 5 516 patients diagnosed with prostate cancer(PCa)at our hospital.Among these,52 patients aged≤50 years were defined as the early-onset group.For the control group,228 patients aged＞50 years were randomly selected at a ratio of 1∶4.4.The early-onset group predominantly presented with elevated PSA levels at diagnosis and had a lower positive rate of digital rectal examination.There were no significant differences in clinical and pathological characteristics between the early-onset group and the control group.Young PCa patients in the low to intermediate risk categories had similar survival prognosis to older patients.However,young patients with high-risk prostate cancer had 5-year progression-free survival rate of 38.4％compared to 55.6％for older patients,and 5-year cancer-specific survival rate of 70.1％compared to 84.1％for older patients,indicating that high-risk young patients exhibited poorer oncological outcomes.
维普
万方数据