No research considering the expression of protein post-translational crotonylation in benign prostate hyperplasia(BPH),and the correlation between crotonylation and clinical urodynamic testing parameters.176 BPH samples collected in our hospital were stained with crotonylation pan-antibody,and the correlation between staining scores and urodynamic test parameters were analyzed.The results showed that 14.77％of BPH tissues had high levels,40.34％had moderate levels,and 44.89％had low levels of crotonylation modification in cytoplasm.43.75％of BPH tissue cell nuclei were stained positive,of which 12 cases showed high levels,18 cases had medium levels,and47 cases had low levels of crotonylation modification.The volume of BPH tissue with high-level cytoplasmic crotonylation modified[(90.15±29.88)ml]was significantly higher than that of medium-level[(52.53±28.68)ml]and low-level[(43.33±19.65)ml]tissues(P＜0.001).Parameters from urodynamics including detrusor pressure and prostate plateau area were significantly higher in the high-level crotonylation group[(63.21±36.25)cmH2O and(2 011.2±518.7)mm·cmH2O]than those in the medium-[(45.0±25.4)cmH2O and(1 319.1±564.4)mm·cmH2O]and low-level[(37.1±19.5)cmH2O and(1 496.4±520.1)mm·cmH2O]groups(P＜0.01).High-level crotonylation modification is related to the proliferation of BPH tissue and the urodynamic performance of patients,which could be involved in the occurrence and development of BPH.
维普
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