年龄因素对瑞马唑仑镇静效力的影响
Effect of age on sedative potency of remimazolam
黄瑾 1张珈硕 1马凤丹 1姜卜维 1王晟昱 1韩亚楠 1王春光1
作者信息
- 1. 保定市第一中心医院麻醉科,保定 071000
- 折叠
摘要
目的 评价年龄因素对瑞马唑仑镇静效力的影响.方法 本研究为前瞻性研究.选取保定市第一中心医院2023年9月1日至11月1日择期在全身麻醉下进行手术的患者,性别不限,年龄40～80岁,BMI18～28kg/m2,ASA分级Ⅰ或Ⅱ级,根据患者年龄,分为中年组(40～64岁)和老年组(65～80岁).采用Dixon序贯法进行试验,瑞马唑仑初始剂量为0.3 mg/kg,给药后3 min内改良警觉/镇静评分≤1分且BIS值≤60判定为镇静有效.瑞马唑仑剂量根据上一例患者镇静有效或无效而减少或增加,剂量梯度为0.03 mg/kg.采用probit法计算瑞马唑仑的半数有效剂量(ED50)及其95％可信区间(CI).记录患者意识消失时间.结果 中年组瑞马唑仑ED50(95％CI)为0.345(0.306～0.384)mg/kg,老年组瑞马唑仑 ED50(95％CI)为 0.322(0.303～0.339)mg/kg,中年组 ED50高于老年组(u=417.00,P=0.022).老年组意识消失时间长于中年组(t=-2.96,P=0.008).结论 对于40～80岁的中老年患者,随年龄增加,瑞马唑仑的镇静效力增强.
Abstract
Objective To evaluate the effect of age on the sedative potency of remimazolam.Meth-ods This was a prospective study.Patients of either sex,aged 40-80 yr,with body mass index of 18-28 kg/m2,of American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ,scheduled for elec-tive surgery with general anesthesia,were divided into middle age group(40-64 yr)and elderly group(65-80 yr)based on the age of the patients.The test was performed by the Dixon's up-and-down method.The initial dose of remimazolam was 0.3 mg/kg.The Modified Observer's Assessment of Alertness/Sedation Scale score ≤1 and bispectral index value ≤60 within 3 min after administration were considered as an ef-fective sedation.The dose of remimazolam was increased/decreased by 0.03 mg/kg based on the sedative effi-cacy in the previous patient.The 50％effective dose(ED50)and 95％confidence interval(CI)of remima-zolam were calculated by the probit method.The time to the loss of consciousness was recorded.Results The ED50(95％CI)of remimazolam was 0.345(0.306-0.384)mg/kg in middle age group,while the ED50(95％CI)of remimazolam was 0.322(0.303-0.339)mg/kg in elderly group.The ED50 was significantly higher in middle age group than in elderly group(u=417.00,P=0.022).The time to loss of consciousness was significantly longer in elderly group than in middle age group(t=-2.96,P=0.008).Conclusions For middle-aged and elderly patients aged 40-80 yr,the sedative potency of remimazolam increases with age.
关键词
年龄因素/瑞马唑仑/清醒镇静/剂量效应关系,药物Key words
Age factors/Remimazolam/Conscious sedation/Dose-response relationship,drug引用本文复制引用
出版年
2024
NETL
NSTL
万方数据