Objective To evaluate the effect of preoperative chemotherapy on the intraoperative he-modynamics and quality of early postoperative recovery in patients undergoing tumor resection.Methods This was a prospective cohort study.A total of 249 patients undergoing malignant tumor resection in the Affiliated Cancer Hospital of Xinjiang Medical University from January to August 2023 were divided into chemotherapy group(group C,n=104)and non-chemotherapy group(group N,n=145)based on their chemotherapy his-tory.Heat rate and mean arterial pressure were recorded on admission(T0),1 min before endotracheal intu-bation(T1),immediately after endotracheal intubation(T2),at skin resection(T3),30 min after endotra-cheal incision(T4),at the end of surgery(Ts)and 24 h after surgery(T6),and the Quality of Recovery-15 score was recorded at T6.The occurrence of hypoxemia,oropharyngeal airway implantation,bucking and aspi-ration after tracheal extubation was observed.The occurrence of postoperative nausea and vomiting was recor-ded.Results Compared with group N,the mean arterial pressure was significantly decreased at T,and in-creased at T2,3,the heart rate was increased at T2-5,the total Quality of Recovery-15 score,postoperative physical comfort score,emotional state score and pain score were decreased at T6,and the incidence of hypox-emia and postoperative nausea and vomiting after tracheal extubation was increased in group C(P＜0.05).Conclusions Preoperative chemotherapy can affect the intraoperative hemodynamic stability and the quality of early postoperative recovery is decreased in patients undergoing preoperative tumor resection.
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