Objective To evaluate the efficacy of oliceridine for patient-controlled intravenous an-algesia(PCIA)after bone tumor resection.Methods In this prospective randomized controlled study,72 patients of either sex,aged 18-64 yr,with a body mass index of 18-28 kg/m2,of American Society of An-esthesiologists Physical Status classification Ⅰ-Ⅲ,who underwent elective bone tumor resection under general anesthesia,were selected and divided into 2 groups(n=36 each)by the random number table method:sufentanil group(group S)and oliceridine group(group O).Combined intravenous-inhalational anesthesia was used in both groups.PCIA was performed from the end of surgery until 48 h after surgery.PCIA solution contained sufentanil 2 μg/kg in normal saline 100 ml in group S and oliceridine 0.4 mg/kg in normal saline 100 ml in group O.The background infusion rate was 2 ml/h,the bolus dose was 2 ml,the lockout interval was 15 min,and the maximum dose per hour was 10 ml in both groups.Flurbiprofen ester 50 mg was intravenously injected as rescue analgesic after operation when numerical rating scale score at rest ≥4 or numerical rating scale score during activity ≥7.The number of effective pressing times of patient-controlled analgesia(PCA),total pressing times of PCA,consumption of analgesics and requirement for rescue analgesia were recorded within 48 h after operation.Ramsay sedation scores were recorded at 2,6,12,24 and 48 h after surgery.The occurrence of adverse reactions and requirement for rescue antiemetic within 48 h after surgery were recorded.The 15-item quality of recovery scale scores were assessed at 24 h before surgery and 24 and 48 h after surgery.The patient satisfaction score and satisfaction rate were recor-ded.Results Compared with group S,the number of effective pressing times of PCA,total pressing times of PCA and consumption of analgesics were significantly reduced within 48 h after operation,the Ramsay se-dation score was significantly increased at 12 h after surgery,the incidence of nausea and vomiting and res-cue antiemetic rate were decreased,and the 15-item quality of recovery scale scores,satisfaction score and satisfaction rate were increased in group O(P＜0.05).There were no significant differences in the rate of rescue analgesia and incidence of respiratory depression,dizziness,pruritus and urinary retention within 48 h after operation(P＞0.05).Conclusions Oliceridine has similar effect to sufentanil for postoperative PCIA,reduces the development of postoperative nausea and vomiting,improves satisfaction,and promotes early postoperative recovery when used in the patients undergoing bone tumor resection.
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