Objective To determine the median effective dose(ED50)of oliceridine combined with propofol for analgesia during induced abortion in patients with different labor histories.Methods This was a prospective study.American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients,aged 18-45 yr,with a body mass index of 20-28 kg/m2,scheduled for elective induced abortion at Henan Provincial People's Hospital(Zhengzhou University People's Hospital)from July 1,2024 to August 20,2024,were selected.Patients were divided into a delivery group(group D)and a non-delivery group(group N)based on their histories of vaginal delivery.The modified Dixon's up and down method was used to conduct the trial.Oliceridine was intravenously injected at a dose of 0.015 mg/kg in the first patient in each group,and the dose was determined based on the intraoperative body movement.The positive response was defined as the body movement of grade 2 or higher during induced abortion.If the response was positive,the next patient received a higher dose of oliceridine,or conversely,a lower dose was given.The ratio be-tween the two successive concentrations was 1.2,and the trial was terminated until 7 turning points were a-chieved.The ED50 and 95％confidence interval were calculated using the Dixon sequential method formula.The occurrence of adverse reactions was recorded.Results A total of 54 patients were included in this study,with 25 in group D and 29 in group N.The ED50 and 95％confidence interval of oliceridine for pain-less abortion were 0.019(0.014-0.031)mg/kg and 0.026(0.020-0.044)mg/kg in group D and group N,respectively.Compared with group D,the ED50 of oliceridine for analgesia during induced abortion was sig-nificantly increased when combined with propofol in group N(P＜0.05).Patients in both groups experienced dizziness after intravenous oliceridine injection,and no other adverse reactions such as injection pain were observed.Conclusions When combined with propofol,the ED50 of oliceridine for analgesia is 0.019 mg/kg and 0.026 mg/kg during induced abortion in patients with and without vaginal delivery history,respectively.The analgesic potency of oliceridine is decreased in patients without a history of vaginal delivery compared to patients with a history of vaginal delivery.
万方数据