Objective To evaluate the effect of age factor on the potency of oliceridine in inhibiting responses to the gastroscopic implantation when combined with propofol.Methods This was a prospective study.American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients of either sex,with a body mass index of 18-27 kg/m2,undergoing elective painless gastroscopy,were divided into 2 groups based on age:adult group(group A:age 18-65 yr)and elderly group(group E:age＞65 yr).Propofol 1.5 mg/kg was slowly injected intravenously 2 min after intravenous injection of oliceridine.Gastroscopy was performed after the patient's eyelash reflex disappeared and the jaw was relaxed.The optimal dose was deter-mined by modified Dixon's up and down method.The initial dose of oliceridine was 0.015 mg/kg,and the ratio between the two successive concentrations was 1.0:1.2.If the patient had a positive response that af-fected the examination operation such as swallowing,bucking and body movement during insertion of the gastroscope,the next patient received a higher dose,or conversely if negative,and a lower dose was given in the next patient.This process was repeated until the 7th turning point occurred.The median effective dose(ED50)and 95％confidence interval of oliceridine in inhibiting responses to gastroscopic implantation were calculated by probit method.Results The ED50(95％confidence interval)of oliceridine in inhibiting re-sponses to gastroscopic implantation was 0.015(0.007-0.023)mg/kg and 0.012(0.007-0.017)mg/kg in group A and group E,respectively.There was no significant difference in ED50 between the two groups(P＞0.05).Conclusions Age factor has no significant effect on the potency of oliceridine in inhibiting respon-ses to gastroscopic implantation when combined with propofol.
关键词
年龄因素/镇痛药,阿片类/二异丙酚/胃镜检查/剂量效应关系,药物
Key words
Age factors/Analgesics,opioid/Propofol/Gastroscopy/Dose-response rela-tionship,drug
万方数据