Objective To compare the anesthetic potency of ciprofol combined with alfentanil in patients with different body mass indexes(BMIs)during gastroscopy.Methods American Society of Anes-thesiologists Physical Status classification Ⅰ or Ⅱ patients,aged 18-64 yr,with a BMI of 18-36 kg/m2,un-dergoing elective painless gastroscopy at Baoding First Central Hospital from October to December 2023,were divided into 3 groups:normal group(18 kg/m2≤BMI＜24 kg/m2),overweight group(24 kg/m2 BMI＜28 kg/m2)and obesity group(BMI ≥28 kg/m2).The 95％effective dose(ED95)of ciprofol during painless gastroscopy was determined by the biased coin design.Alfentanyl 5 μg/kg and ciprofol were intrave-nously injected for anesthesia induction.Gastroscopy was performed after the patient's eyelash reflex disap-peared,the jaw muscle was relaxed and the Modified Observer's Assessment of Alertness/Sedation Scale score ≤ 1.The initial dose of ciprofol was 0.2 mg/kg with a dose gradient of 0.04 mg/kg.The positive re-sponse were defined as the Modified Observer's Assessment of Alertness/Sedation Scale score still＞1 after 3 min of ciprofol injection or any other responses affecting the procedure,such as body movement,bucking,or swallowing during insertion of the endoscope.If the response was positive,the next patient received a higher dose of ciprofol,or conversely if negative,the next patient received the same dose(95％probability)or a lower dose(5％probability).Each group was completed with 40 cases.Results The ED95 and 95％confidence intervals of ciprofol in normal,overweight and obese groups were 0.266(0.246,0.285)mg/kg,0.218(0.189,0.244)mg/kg,0.191(0.156,0.220)mg/kg,respectively.The ED95 of ciprofol was signif-icantly lower in overweight and obese groups than in normal group(P＜0.05).Conclusions Overweight and obesity can increase the anesthetic potency of ciprofol in patients undergoing gastroscopy.
关键词
体重变化/环泊酚/阿芬太尼/胃镜检查/剂量效应关系,药物
Key words
Body weight changes/Ciprofol/Alfentanyl/Gastroscopy/Dose-effect relation-ship,drug
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