Association between septic shock and tracheal injury in intensive care unit patients with invasive ventilation:a single-centre prospective cohort study
Association between septic shock and tracheal injury in intensive care unit patients with invasive ventilation:a single-centre prospective cohort study
Objective To evaluate the association between septic shock and tracheal injury in the in-tensive care unit(ICU)patients with invasive ventilation.Methods This was a prospective single-centre co-hort study.Patients who underwent invasive mechanical ventilation at the Department of Anesthesia Critical Care Medicine of the Second Hospital of Hebei Medical University from May 31,2020 to March 5,2022 were selected.The general characteristics of patients,reasons for ICU admission,vital signs,laboratory test re-sults,Acute Physiology and Chronic Health Evaluation Ⅱ scores,Charlson Comorbidity Index,size of endotra-cheal tube,presence or absence of septic shock,oxygenation index,duration of intubation,consumption of norepinephrine and epinephrine,and tracheal injury scores at the time of extubation were recorded.Univariate linear regression analysis was used to identify the risk factors for tracheal injury,followed by adjustment using multivariate linear regression analysis.Results Ninety-seven patients were ultimately included,and the aver-age age was(56.6±16.5)yr,with 64.9％being male.The results of adjusted linear regression showed that septic shock was associated with tracheal injury scores(β=2.99,95％confidence interval 0.70-5.29).Sub-group analysis revealed a stronger correlation with a duration of intubation ≥ 8 days(P=0.013).Conclusions Patients with septic shock exhibit significantly higher tracheal injury scores compared with those without septic shock,suggesting that septic shock may serve as an independent risk factor for tracheal injury.
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