摘要
Toll样受体4（TLR4）作为一种模式识别受体，是先天免疫炎症反应的关键触发点。研究证实TLR4信号通路介导的免疫炎症反应在脑卒中、阿尔茨海默病、帕金森病等神经系统疾病中发挥着关键作用。本文主要就TLR4信号通路在神经系统疾病中的研究进展做一综述，为TLR4用于神经系统疾病的靶向治疗拓展新思路。
Abstract
Toll-like receptor 4 (TLR4), as a kind of pattern recognition receptor, is the key trigger of innate immune inflammatory response. Studies have confirmed that TLR4 signaling pathway-mediated immune inflammatory response plays a key role in stroke, Alzheimer's disease, Parkinson's disease, and other neurological diseases. This article mainly reviews the research progress of TLR4 signaling pathway in nervous system diseases, so as to inspire new ideas for TLR4-targeted therapy for nervous system diseases.
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