摘要
卵圆孔未闭（PFO）是指原发隔和继发隔未能完全融合而留有缝隙样结构，与以血栓形成、栓塞为基础的隐源性卒中和偏头痛等疾病密切相关。充分了解PFO相关血栓形成的机制将有助于临床识别病理性PFO及进行个体化管理，使患者充分获益。本文拟从反常栓塞、原位血栓形成、左心房功能改变及血液高凝状态等方面对PFO相关血栓形成机制的研究进展进行综述，以期为后续PFO相关疾病的高危因素及预防策略研究提供理论基础。
Abstract
Patent foramen ovale (PFO) refers to the gap-like structure left after the septum primum and septum secundum failed to fully fuse, which is closely related to cryptogenic stroke and migraine based on thrombosis and embolism. Gaining a comprehensive understanding of the underlying mechanisms of PFO-associated thrombosis will greatly contribute to the clinical identification of the pathology of PFO and individualized management, benefiting patients fully. This article reviewed the research progress on PFO-related thrombosis mechanisms from paradoxical embolism, in situ thrombosis, left atrial function changes to hypercoagulable state, providing a theoretical basis for the following research on high-risk factors and prevention strategies of PFO-related diseases.
基金项目
北京大学第三医院院临床重点项目(BYSYZD2022034)
万方数据