摘要
缺血性卒中（IS）是目前全球最常见的神经系统疾病之一，其常见的危险因素为高血压、糖尿病、肥胖、衰老、血栓及粥样斑块形成等，这些危险因素可导致IS患者预后不佳。肠道菌群在近年来备受关注，着眼于菌群-肠道-脑轴的研究通过揭示肠道菌群、胃肠道及中枢神经系统之间的交互作用，从而发现肠道菌群与神经系统疾病的内在联系，最终可能揭示神经系统疾病发生发展的机制并寻求新的治疗潜在靶点。目前，越来越多的研究着眼于肠道菌群与IS相关危险因素之间的联系，发现菌群-肠道-脑轴在IS的发病过程中具有重要作用。本文就肠道菌群失调与IS相关危险因素之间的相互作用进行文献综述，以期为揭示IS发生发展的机制及寻找潜在的治疗方式提供更全面的视角及思路。
Abstract
Ischemic stroke (IS) is one of the most common neurological disease worldwide today. The risk factors of IS, such as hypertension, diabetes, obesity, aging, and formation of thrombus and atheromatous plaque, are demonstrated to be able to lead to poor prognosis of patients. The gut microbiota has attracted more attention in recent years, and the study focused on microbiota-gut-brain axis might help to reveal the mechanisms of the neurological and new therapeutic targets of IS. The microbiota-gut-brain axis describes the crosstalk between the gut microbiota, intestine, and center nervous system. At present, an increasingly number of studies have started to focus on the correlation between gut microbiota and risk factors of IS, indicating that the microbiota-gut-brain axis plays an important role in the pathogenesis of IS. This article reviews studies of how the gut microbiota alterations affect the progression of these risk factors, and how the onset of the risk factors would change the composition of gut microbiota. The primary purpose of the current study is to provide more comprehensive perspectives and collective ideas, in order to encourage more potential treatment for IS based on the microbiota-gut-brain axis.
基金项目
首都医科大学附属北京朝阳医院金种子基金资助项目(CYJZ202124)
万方数据