摘要
脑静脉窦及静脉血栓形成统称为脑静脉血栓形成（CVT），主要见于中青年女性，具有较低的发病率和复杂的病因。关于CVT的发生发展机制仍然知之甚少。众所周知，血栓形成往往伴有免疫炎症反应，而免疫炎症反应在静脉血栓形成中的参与度似乎更广、更具独特性。目前为止，关于免疫炎症反应在CVT中作用的综述比较欠缺。本文整理了肥胖、感染以及性激素变化等高危状态中免疫炎症反应参与血栓形成的机制，总结了血栓形成后中枢神经系统固有免疫和系统免疫等因素引起的继发性脑损伤机制，讨论了针对免疫炎症反应靶点进行干预对预防和改善CVT预后的研究现状。深入了解免疫炎症反应在CVT中的作用及机制，加快转化研究以便更好地改善疾病预后是必要的。
Abstract
Cerebral venous sinus and venous thrombosis are collectively called cerebral venous thrombosis (CVT), which is mainly seen in young and middle-aged women and has a low incidence rate and complex causes. The mechanisms underlying the development of CVT are still poorly understood. It is known that thrombosis is often accompanied by an immune-inflammatory response, which appears to be more widespread and unique in venous thrombosis. So far, there is a lack of review on the role of immune-inflammatory response in CVT. This article summarizes the mechanisms by which immune-inflammatory responses participate in thrombosis in high-risk states such as obesity, infection, and changes in sex hormone levels. Secondly, this article summarizes the mechanisms of secondary brain injury caused by factors such as innate immunity and systemic immunity in the central nervous system after thrombosis. Finally, the current research status of intervention on immune-inflammatory response targets to prevent and improve the prognosis of CVT is discussed. It is necessary to gain a deeper understanding of the role and mechanism of immune-inflammatory responses in CVT and to accelerate translational research to better improve disease prognosis.
基金项目
国家自然科学基金委员会杰出青年科学基金项目(81825007)
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