摘要
目的 探讨艾滋病(AIDS)病案资料中抗逆转录病毒药物所致皮疹的临床特点.方法 回顾性分析2010年01月01日-2012年12月31日成都市公共卫生临床医疗中心艾滋病病案资料,对16例住院患者抗逆转录病毒药物性皮疹出现时间、临床表现、导致皮疹的药物种类、治疗效果等临床特点进行总结.结果 1)该组病案中AIDS患者抗逆转录病毒药物治疗中皮疹发生率0.8％,绝大多数为接受含奈韦拉平方案治疗者(15例,93.7％);2)皮疹出现时间1-37天,平均16.9±11.2天;3)皮疹形态以斑丘疹为主(15例,93.7％);4)皮疹分级以1-2级为主(10例,62.5％);5)经积极抗过敏治疗后均能消退,治疗时间3-30天,平均12.7±8.1天;6)所有患者均能在医生指导下换用或继续原方案抗病毒治疗.结论 AIDS抗逆转录病毒药物治疗中易出现皮疹,尤其是奈韦拉平,皮疹多出现于治疗后1月内,以1-2级的斑丘疹为主,经积极抗过敏治疗后均能消退,所有患者均能在医生指导下换用或继续原方案抗病毒治疗.
Abstract
Objectives To explore the clinical characteristics of rashes induced by anti-retroviral treatment (ART) of AIDS patients by the clinical medical records materials.Methods To conduct a retrospective study on the clinical medicalrecords materials of AIDS patients in the Clinical Medical Treatment Center of Public Health in Chengdu from January 1st 2010 to December 31th 2012.and make analysis and summarize on the clinical characteristics of 16 cases of AIDS patients with ART included the appearing time.clinical manifestation.types of drugs that caused skin rashes.therapeutic effect and so on.Results 1) The incidence rate of rashes among all the recorded AIDS patients with ART in this study was 0.8％ and most patients were treated with Nevirapine (15 cases.93.7％) ; 2) Rashes appeared in 1-37 days after ART with average of 16.9 ± 11.2 days; 3) Most rashes were maculopapule (15cases,93.7％) ; 4) Most of the rashes cases were 1-2 level according to the classification of rash severity; 5) All rashes faded after 3-30 days of positive allergy treatment.with average of 12.7 ± 8.1 treatment days; 6) All patients kept in ART with original treatments plans or alternative plans suggested by doctors.Conclusions Rashes were a common side effect of ART in the treatment of AIDS patients especially in Nevirapine.Most rashes happened within one month after ART and most were 1-2 level maculopapule which could fade after positive allergy treatment.And all patients could keep in ART with original treatments plans or alternative plans suggested by doctors.
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维普
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