Cardiovascular Disease Incidence and Risk Factors in Elderly Patients with Chronic Obstructive Pulmonary Disease Combined with Renal Insufficiency
Objectives This study aims to investigate the incidence of cardiovascular diseases in elderly patients with chronic obstructive pulmonary disease combined with renal insufficiency and analyze the risk factors.Methods 219 elderly patients with COPD combined with renal insufficiency admitted to a hospital from January 31,2018 to January 31,2023 were retrospectively selected.The incidence of CAD was statistically analyzed.According to the occurrence of cardiovascular diseases,the elderly patients with chronic obstructive pulmonary disease and renal insufficiency were divided into cardiovascular disease group and non-cardiovascular disease group.The differences in clinical and laboratory data between CAD and non-CAD groups were compared.Multivariate Logistic regression was used to analyze the influencing factors of CAD in elderly patients with COPD combined with renal insufficiency.Results Among 219 patients,107 patients developed CAD(cardiovascular disease group),and 112 patients did not develop CAD(non-cardiovascular disease group).Age,diabetes rate,frequency of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)≥3 times per year,fasting blood glucose(FPG),and neutrophil count/lymphocyte count ratio in CAD group were higher than those in non-CAD group(P＜0.05).The percentage of forced expiratory volume in the first second to the predicted value,left ventricular ejection fraction,estimated glomerular filtration rate,hemoglobin,and 1,25-hydroxyvitamin D were lower than those in the non-CAD group(P＜0.05).Multivariate Logistic regression analysis showed that the frequency of AECOPD ≥3 times per year and high NLR were the risk factors for CAD in COPD patients with renal insufficiency(P＜0.05),while eGFR,1,25(OH)2D,and HGB were the protective factors(P＜0.05).Conclusions Elderly patients with COPD combined with renal insufficiency have a higher risk of CAD.High frequency of AECOPD and NLR are risk factors for CAD.Increasing eGFR,1,25(OH)2D and HGB can reduce the risk of CAD.
NETL
NSTL
万方数据
维普
