Meta-analysis on Risk Factors for Clinical Prognosis in Patients with Multidrug-Resistant Bacterial Infections
Objectives This study aims to use Meta-analysis to conduct a comprehensive judgment and systematic evaluation of various factors that affect the clinical outcomes of patients with multidrug-resistant bacterial infections.Methods Literature was searched from January 1,2011,to December 31,2020,according to inclusion and exclusion criteria to extract data.Evaluation was conducted to assess the research quality.RevMan 5.3 was used for meta-analysis.Results A total of 438 literatures were retrieved and 10 were included in the study,with 638 cases in the poor prognosis group and 1059 cases in the improvement group.22 influencing factors were included.The results of comprehensive analysis revealed statistically significant differences between the poor prognosis group and the improvement group in various factors:age(95％CI:3.98,6.92),chronic kidney disease(95％CI:1.12,3.30),malignant tumors(95％CI:1.15,2.08),cardiovascular diseases(95％CI:1.15,1.89),immune abnormalities(95％CI:1.75,3.27),mechanical ventilation(95％CI:2.51,4.88),endotracheal intubation or tracheostomy(95％CI:1.17,11.65),indwelling urinary catheter(95％CI:1.10,8.00),deep vein catheterization(95％CI:1.76,5.34),nasogastric tube(95％CI:1.03,6.43),antibiotic combination(95％CI:1.01,2.07),APACHE Ⅱ score(95％CI:1.74,5.85),and hospital stays(95％CI:-13.26,-10.88)(P＜0.05).Conclusions Patients with multidrug-resistant bacterial infections,particularly those of advanced age,with underlying diseases,a history of invasive procedures,higher antibacterial combination usage,and higher APACHE Ⅱ scores,are at a higher risk of mortality and have a poorer prognosis.Judging,identifying,and responding to various risk factors in a timely manner,and adopting active and effective measures to reduce the mortality rate,are important for improving the quality of life of patients.
万方数据
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