摘要
目的 分析LMR、SOD、ACR在2型糖尿病(T2DM)病情发展过程中的意义,研究三指标与T2DM出现并发症的相关性,探讨三者对T2DM的预测价值.方法 收集2019年1月1日-2021年12月31日在某院住院治疗的214例T2DM患者的临床资料,其中男145例,女69例,分析有无并发症组、不同并发症数量组患者各指标的差异,找出其中的危险因素,对有差异的指标进行二元logistics回归分析,并做ROC曲线.结果 无并发症组的男性比例高,有并发症组较无并发症组年龄、收缩压、ACR、LMR水平高,SOD水平低(P:0.036,＜0.001,0.003,＜0.001,0.011,＜0.001).无并发症、一种并发症、多种并发症三组间性别、年龄、收缩压、ACR、LMR、SOD水平具有统计学差异(P:＜0.001,0.033,＜0.001).LMR/性别、LMR/年龄、ACR/SOD具有相关性(P＜0.05),年龄/性别、收缩压/年龄、ACR/年龄、SOD/年龄、ACR/收缩压、SOD/收缩压、LMR/ACR、SOD/LMR具有较显著的相关性(P＜0.01).ACR为T2DM出现并发症的危险因素(P=0.033),SOD为保护性因素(P=0.001).ACR、SOD在有无并发症组间的ROC曲线下面积分别为0.732、0.725,两者联合预测值为0.756.SOD为T2DM出现多种并发症的保护性因素(P--0.005),其在不同数量并发症组间的ROC曲线下面积为0.725.结论 T2DM无并发症患者LMR水平较高,ACR是T2DM出现并发症的危险因素,SOD是T2DM出现一种至多种并发症过程中的保护性因素.联合检测ACR、SOD对T2DM出现并发症有一定的预测价值.
Abstract
Objectives To analyze the significance of Lymphomonocyte ratio(LMR),Superoxide dismutase(SOD)and Urinary microalbumin/creatinine ratio(ACR)in the development of type 2 diabetes mellitus(T2DM),study the correlation between the three indicators and the complications of T2DM,and explore the predictive value of the three indicators on T2DM.Methods Clinical data of 214 T2DM patients hospitalized in a hospital from January 1st,2019 to December 31st,2021 were collected,including 145 males and 69 females.We analyzed the differences in various indicators among patients with or without complications and with varying numbers of complications,identifying the risk factors.Binary logistics regression analysis was conducted on the indicators that showed differences,and ROC curves were made.Results The proportion of males was higher in the group without complications.The age,systolic blood pressure,ACR and LMR levels were higher while SOD levels were lower in the group with complications as compared to those without complications(P:0.036,＜0.001,0.003,＜0.001,0.011,＜0.001).There were statistically significant differences in gender,age,systolic blood pressure,ACR,LMR and SOD levels among groups with no complications,one complication,and multiple complications(P:＜0.001,0.033,＜0.001).LMR/Gender,LMR/Age and ACR/SOD showed correlation(P＜0.05),while Age/Gender,Systolic Blood Pressure/Age,ACR/Age,SOD/Age,ACR/Systolic Blood Pressure,LMR/ACR and SOD/LMR showed significant correlation(P＜0.01).ACR was a risk factor for the occurrence of complications in T2DM(P=0.033),and SOD was a protective factor(P=0.001).The Area Under ROC curve(AUC).f ACR and SOD between groups with or without complications was 0.732 and 0.725,respectively,and their combined predictive value was 0.756.SOD was a protective factor for the occurrence of multiple complications in T2DM(P=0.005),with an AUC of 0.725 between groups with different numbers of complications.Conclusions Patients with T2DM without complications had higher LMR levels.ACR was a risk factor for the occurrence of complications in T2DM,while SOD was a protective factor during the process of occurrence from one to multiple complications.The combined detection of ACR and SOD had certain predictive value for the presence of complications in T2DM.
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万方数据