Predictive Value of LMR,SOD and ACR in T2DM Complications
Objectives To analyze the significance of Lymphomonocyte ratio(LMR),Superoxide dismutase(SOD)and Urinary microalbumin/creatinine ratio(ACR)in the development of type 2 diabetes mellitus(T2DM),study the correlation between the three indicators and the complications of T2DM,and explore the predictive value of the three indicators on T2DM.Methods Clinical data of 214 T2DM patients hospitalized in a hospital from January 1st,2019 to December 31st,2021 were collected,including 145 males and 69 females.We analyzed the differences in various indicators among patients with or without complications and with varying numbers of complications,identifying the risk factors.Binary logistics regression analysis was conducted on the indicators that showed differences,and ROC curves were made.Results The proportion of males was higher in the group without complications.The age,systolic blood pressure,ACR and LMR levels were higher while SOD levels were lower in the group with complications as compared to those without complications(P:0.036,＜0.001,0.003,＜0.001,0.011,＜0.001).There were statistically significant differences in gender,age,systolic blood pressure,ACR,LMR and SOD levels among groups with no complications,one complication,and multiple complications(P:＜0.001,0.033,＜0.001).LMR/Gender,LMR/Age and ACR/SOD showed correlation(P＜0.05),while Age/Gender,Systolic Blood Pressure/Age,ACR/Age,SOD/Age,ACR/Systolic Blood Pressure,LMR/ACR and SOD/LMR showed significant correlation(P＜0.01).ACR was a risk factor for the occurrence of complications in T2DM(P=0.033),and SOD was a protective factor(P=0.001).The Area Under ROC curve(AUC).f ACR and SOD between groups with or without complications was 0.732 and 0.725,respectively,and their combined predictive value was 0.756.SOD was a protective factor for the occurrence of multiple complications in T2DM(P=0.005),with an AUC of 0.725 between groups with different numbers of complications.Conclusions Patients with T2DM without complications had higher LMR levels.ACR was a risk factor for the occurrence of complications in T2DM,while SOD was a protective factor during the process of occurrence from one to multiple complications.The combined detection of ACR and SOD had certain predictive value for the presence of complications in T2DM.
Type 2 diabetes mellitusType 2 diabetic complicationsLymphomonocyte ratioSuperoxide dismutaseUrinary microalbumin/creatinine ratio
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