Observation on the Efficacy of Low Dose Levothyroxine in Elderly Patients with Protein-energy Malnutrition and Euthyroid Sick Syndrome
Objective To observe the efficacy and safety of low Dose Levothyroxine on improving hemoglobin and albumin levels in elderly patients with protein-energy malnutrition and euthyroid sick syndrome.Methods A total of 65 elderly patients aged over 65 years old who were admitted to a hospital from January 1st,2017 to August 31st,2021 with hypoproteinemia,anemia and normal thyroid syndrome were selected,and the patients were randomly divided into the treatment group(35 cases)and the control group(30 cases).Both groups were given more than 20 kcal/kg/body weight daily calories,0.8g/kg/body weight protein daily,conventional primary disease treatment.In the treatment group,a small dose of levothyroxine sodium 25ug/d was added on the basis of conventional nutritional treatment and primary disease treatment for 3 months.The changes of thyroid function,hemoglobin,blood albumin,prealbumin and resting heart rate were observed before and after treatment.Results Compared with the control group,there were no significant differences in HB,ALB and PAL levels and thyroid function between the two groups before treatment(P＞0.05).Compared with the control group,after 3 months of low-dose levothyroxine sodium supplementation,hemoglobin(112.6±13.3)g/l,prealbumin(173.3±55.1)mg/l,FT4(1.51±0.23)g/dl were increased in the treatment group,and there were statistical differences between the groups(P＜0.05).There was no significant difference in heart rate between the two groups.Conclusions On the basis of routine treatment in elderly patients with protein-energy malnutrition combined with thyroid dysfunction syndrome,low-dose levothyroxine tablets could increase the levels of hemoglobin and albumin,and had no significant effect on heart rate,but it needed to be further confirmed by expanding clinical sample data.
NETL
NSTL
万方数据
