A Case of Infective Endocarditis Caused by Cupriavidus Paucula and Literature Review
Cupriavidus paucula is a non-fermenting,oxidase-positive,Gram-negative rod bacterium that does not form spores.It is considered an opportunistic pathogen and rarely causes infections in humans.Patients infected with it often have identifiable immunodeficiency factors.In this study,we present a clinical case of infective endocarditis caused by Cupriavidus paucula in a middle-aged male patient without apparent immunodeficiency.Based on the literature review,we hypothesize that the persistent reduction of T lymphocytes associated with COVID-19 infection,along with human cytomegalovirus infection and hyperglycemia in diabetes,may have contributed to the impaired immune function,particularly cellular immunity,thereby increasing the susceptibility to opportunistic pathogens in this case.This case highlights the importance of pathogen detection and being vigilant about opportunistic pathogens or atypical infections in patients presenting with recurrent unexplained infectious fever after COVID-19 infection.Prompt selection of sensitive antibiotics based on the pathogen detection results is crucial to prevent inadequate treatment that may fail to cover the causative agents,leading to unfavorable outcomes.
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