With the continuous development and progress of medicine,there has been a deeper understanding of the nature of amyloidosis,leading to changes in its disease naming,corresponding disease characteristics,and morphological coding.This article summarizes the latest clinical diagnostic types and standard consensus of amyloidosis,including systemic immunoglobulin light chain amyloidosis,formerly known as primary systemic amyloidosis,and other types of amyloidosis.Systemic immunoglobulin light chain amyloidosis has changed from the previously defined borderline tumor D47.7 M9769/1 to systemic malignant plasma cell tumor C90.2 M9731/3.Other types of amyloidosis are classified into different subcategories under section E85 of the ICD-10 anatomical system,based on whether they are acquired or inherited,localized or systemic,and the type of amyloid proteins.Localized amyloidosis is generally encoded by the Star Sword number,while β Idiopathic Alzheimer's disease caused by amyloidosis is classified as G30.4.Coders should master the nature of amyloidosis and ICD coding rules and accurately classify amyloidosis to improve coding accuracy.