首页|含有三七提取物和丹皮酚的牙膏对减轻牙龈炎症的临床研究

含有三七提取物和丹皮酚的牙膏对减轻牙龈炎症的临床研究

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目的 研究使用含有三七提取物和丹皮酚成分的牙膏,在减轻牙龈炎症的临床疗效.方法 采用随机双盲安慰剂平行对照设计,将2024年1月29日-2024年4月30日在某三级综合医院口腔科就诊的63例龈炎或牙周炎(Ⅰ期-Ⅱ期)患者,以随机、双盲的方法分为试验组31例与对照组32例.对照组采用不含三七提取物和丹皮酚成分的牙膏.试验组采用含有三七提取物和丹皮酚成分的牙膏.两组用同一种刷牙方法,比较两组患者第1月、2月时牙龈指数,出血指数,菌斑指数,探诊出血百分比等临床牙周指标.结果 与入组日检查相比,使用试验组牙膏患者的牙龈指数和出血指数在第1月检查时均有显著下降,与同期对照组相比,差异具有统计学意义(P<0.05),探诊出血百分比与菌斑指数均值也均有明显下降;在第2月的临床牙周指标检查时,试验组牙膏患者的牙龈指数和出血指数与对照组相比,同样具有下降趋势,具有统计学意义(P<0.05),但菌斑指数均值与第1月相比小幅上升,而探诊出血百分比均值依然呈下降趋势.试验期间无不良事件发生.结论 使用含三七提取物和丹皮酚的牙膏患者在2个月后,牙龈指数均值、出血指数均下降,含有三七提取物和丹皮酚的牙膏在一定程度上具有减轻牙龈出血及牙龈炎症的功效.
Clinical Study on the Effect of Toothpaste Containing Panax Notoginseng Extract and Paeonol on Alleviating Gingival Inflammation
Objectives This study aims to investigate the use of toothpaste containing Panax notoginseng extract and paeonol to provide a clinical treatment basis for alleviating gingival inflammation.Methods A randomized,double-blind,placebo-controlled,parallel design was used to randomly divide 63 patients with gingivitis or periodontitis(stage Ⅰ-Ⅱ)who visited the Department of Stomatology of a tertiary general hospital from January 29,2024 to April 30,2024 into an experimental group of 31 cases and a control group of 32 cases.The control group used toothpaste without Panax notoginseng extract and paeonol,while the experimental group used toothpaste containing Panax notoginseng extract and paeonol.The two groups used the same toothbrushing method.Clinical periodontal indices such as gingival index,bleeding index,plaque index,and percentage of bleeding on probing between the two groups at 1 month and 2 months were compared.Results Compared with the baseline examination,the gingival index and bleeding index of patients using toothpaste in the experimental group decreased significantly at the first-month examination and the difference was statistically significant(P<0.05)compared with the control group during the same period.The percentage of bleeding on probing and the mean of plaque index also decreased significantly.In the second month of clinical periodontal index examination,the gingival index and bleeding index of the experimental group toothpaste patients showed a downward trend compared with the control group,which was statistically significant(P<0.05).However,the mean plaque index increased slightly compared with the first month,while the mean percentage of bleeding on probing continued to decline.No adverse events occurred during the trial.Conclusions After 2 months of using toothpaste containing Panax notoginseng extract and paeonol,the mean gingival index and bleeding index of patients decreased.Toothpaste containing Panax notoginseng extract and paeonol has the effect of reducing gingival bleeding and gingivitis to a certain extent.

GingivitisPanax notoginseng extractPaeonolDental plaque

周旭迪阳、耿佳琪、王雪媛、谷雅楠、赵丹丹、王双、张冬雪

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首都医科大学附属北京朝阳医院口腔科,北京市,100020

北京市通州区次渠社区卫生服务中心,北京市,101111

牙龈炎 三七提取物 丹皮酚 牙菌斑

2024

中国病案
中国医院协会

中国病案

CSTPCD
影响因子:1.197
ISSN:1672-2566
年,卷(期):2024.25(11)