Clinical Study on the Effect of Toothpaste Containing Panax Notoginseng Extract and Paeonol on Alleviating Gingival Inflammation
Objectives This study aims to investigate the use of toothpaste containing Panax notoginseng extract and paeonol to provide a clinical treatment basis for alleviating gingival inflammation.Methods A randomized,double-blind,placebo-controlled,parallel design was used to randomly divide 63 patients with gingivitis or periodontitis(stage Ⅰ-Ⅱ)who visited the Department of Stomatology of a tertiary general hospital from January 29,2024 to April 30,2024 into an experimental group of 31 cases and a control group of 32 cases.The control group used toothpaste without Panax notoginseng extract and paeonol,while the experimental group used toothpaste containing Panax notoginseng extract and paeonol.The two groups used the same toothbrushing method.Clinical periodontal indices such as gingival index,bleeding index,plaque index,and percentage of bleeding on probing between the two groups at 1 month and 2 months were compared.Results Compared with the baseline examination,the gingival index and bleeding index of patients using toothpaste in the experimental group decreased significantly at the first-month examination and the difference was statistically significant(P<0.05)compared with the control group during the same period.The percentage of bleeding on probing and the mean of plaque index also decreased significantly.In the second month of clinical periodontal index examination,the gingival index and bleeding index of the experimental group toothpaste patients showed a downward trend compared with the control group,which was statistically significant(P<0.05).However,the mean plaque index increased slightly compared with the first month,while the mean percentage of bleeding on probing continued to decline.No adverse events occurred during the trial.Conclusions After 2 months of using toothpaste containing Panax notoginseng extract and paeonol,the mean gingival index and bleeding index of patients decreased.Toothpaste containing Panax notoginseng extract and paeonol has the effect of reducing gingival bleeding and gingivitis to a certain extent.