Predictive value of leptin and irisin on left ventricular systolic function in patients with acute ST-segment elevation myocardial infarction
Objective To investigate the predictive value of leptin and irisin for left ventricular systolic function(LVSF)in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods A retrospective analysis was conducted on 96 STEMI patients admitted to the Second Affiliated Hospital of Hebei North University from January 2021 to January 2024.Patients with left ventricular ejection fraction(LVEF)＜50％were included in the observation group(n=42),and those with LVEF≥50％were included in the control group(n=54).The correlation between leptin,irisin,and circumferential end-systolic stress(cESS)as well as myocardial energy expenditure(MEE)in patients with STEMI was analyzed.The independent correlations between leptin,irisin,and the risk of LVSF impairment were analyzed.A restricted cubic spline model was established to analyze the dose-response relationship between leptin,irisin,and the risk of LVSF impairment in STEMI patients.Results The results of multivariate Logistic regression analysis showed that a significant positive correlation was observed between leptin and cESS,MEE,while a significant negative correlation was found between irisin and cESS,MEE(all P＜0.001).Leptin exhibited an independent positive correlation,while irisin showed an independent negative correlation with LVSF impairment(both P＜0.05).There was a nonlinear dose-response relationship between leptin,irisin,and the risk of LVSF impairment.When leptin was ≤15 μg/L,the risk of LVSF impairment in STEMI patients increased with increasing leptin levels[odds ratio(OR)=1.517,95％confidence interval(CI):1.118-1.735,P＜0.001].When irisin was ≥0.89 mg/L,the risk of LVSF impairment in STEMI patients increased with decreasing irisin levels(OR=-1.593,95％CI:-2.818 to-1.326,P＜0.001).Conclusions Leptin has an independent positive correlation with LVSF impairment,while irisin shows an independent negative correlation.There exists a nonlinear dose-response relationship between leptin,irisin,and the risk of LVSF impairment.Specifically,when leptin is ≤15 μg/L,the risk of LVSF impairment in STEMI patients increases with increasing leptin levels;conversely,when irisin is ≥0.89 mg/L,the risk of LVSF impair-ment increases with decreasing irisin levels.
万方数据
维普
