Relationship between serum levels of heparin cofactor-Ⅱ and dipeptidyl peptidase 4 and coronary artery in-stent restenosis after drug-coated balloon dilatation
Objective To investigate the relationship between serum levels of heparin cofactor-Ⅱ(HC-Ⅱ)and dipeptidyl peptidase 4(DPP4)and coronary artery in-stent restenosis(ISR)after drug-coated balloon(DCB)dilation.Methods A total of 158 ISR patients who underwent DCB expansion in Yan'an University Affiliated Hospital from January 2021 to March 2023 were selected.The clinical data were collected,and the serum levels of HC-Ⅱ and DPP4 were detected by enzyme-linked immunosorbent assay.Taking ISR after DCB expansion in ISR patients as the dependent variable,a multivariate unconditional Logistic regression model was established to determine its influencing factors.Receiver operating characteristic(ROC)curve was drawn to evaluate the value of serum HC-Ⅱ and DPP4 levels in predicting ISR after DCB dilatation.Results After 1 year of follow-up,54 of 158 ISR patients(34.2％)with ISR after DCB expansion were included in the ISR group,and 104 patients were in the non-ISR group.Multivariate Logistic regression analysis showed that increased stenosis rate of the official carity,increased neutrophil to lymphocyte ratio and increased DPP4 were independent risk factors for ISR after DCB expansion,and increased HC-Ⅱ was an independent protective factor(all P＜0.05).The ROC curve showed that the area under the curve(AUC)of the combination of serum HC-Ⅱ and DPP4 levels in predicting ISR after DCB dilatation was 0.873,which was larger than 0.789 and 0.788 of HC-Ⅱ and DPP4 levels alone(all P＜0.05).Conclusion The decrease of serum HC-Ⅱ level and the increase of DPP4 level are closely related to ISR after DCB dilatation.The combination of serum HC-Ⅱ and DPP4 levels has a higher value in predicting coronary artery ISR after DCB dilatation in patients with ISR.
In-stent restenosisDrug-coated balloonHeparin cofactor-ⅡDipeptidyl peptidase 4Predictive value
万方数据
维普
