Study on the application of porcine fibrin adhesive in coronary artery bypass grafting
Objective To evaluate the efficacy,safety and economy of porcine fibrin sealant in coronary artery bypass grafting(CABG).Methods The clinical data of 143 patients who underwent off-pump CABG in the Coronary Surgery Center,Beijing Anzhen Hospital,Capital Medical University from March to October 2023 were retrospectively analyzed.Among them,67 patients were treated with porcine fibrin adhesive during the operation(observation group),and 76 patients were not treated(control group).The intensive care unit(ICU)stay time,postoperative drainage volume,drainage tube indwelling time,postoperative hospital stay,postoperative blood product usage rate,coagulation function and drug allergy were analyzed.Results There was no significant differ-ence in ICU stay time,postoperative drainage volume and postoperative blood product usage between the two groups(all P＞0.05).The postoperative drainage tube indwelling time and hospitalization time of the observation group were shorter than those of the control group[44(38,49)hvs46(41,65)h,5(4,6)dvs5(5,6)d](both P＜0.05).There was no significant difference in prothrombin activity,activated partial thromboplastin time and fibrinogen level between the two groups before operation and on the first day after operation(all P＞0.05).On the first day after operation,the level of fibrin degradation products in the observation group was higher than that in the control group(P＜0.05).There was no drug-related allergic reaction in the two groups,and there was no significant difference in hospitalization costs between the two groups(P＜0.05).Conclusion The use of porcine fibrin adhesive during CABG has good biocompatibility,which can shorten the postoperative drainage tube indwelling time and postoperative hospital stay,but does not reduce the postoperative drainage volume and blood transfusion rate,and has no significant effect on the hospitalization cost of patients.
万方数据
维普
