Analysis of the clinical and imaging features of patients with pulmonary Tropheryma whipplei infection
Objective To analyze and summarize the clinical data of patients with pulmonary Tropheryma whipplei(TW)infection,and further improve the understanding of pulmonary TW infection.Methods The clinical data(including basic information,test results,chest CT,treatment and outcome)of 7 patients with pulmonary TW infection admitted to the Department of Respiratory Medicine,Civil Aviation General Hospital from September 1,2021 to January 31,2023 were collected and retrospectively analyzed.Results Among the 7 patients with pulmonary TW infection,there were 3 males and 4 females,with age of 67(45,73)years.All patients had at least one underlying disease in their past medical history that may lead to abnormal immune function,the most common being coronary atherosclerotic heart disease.The white blood cell counts of all patients were in the normal range,but the percentage of neutrophils in 2 patients with mixed infection was significantly increased,which reached 86.9％and 95.9％,respectively.Chest CT showed ground glass density shadow,diffuse small nodular shadow or patchy shadow.All the 7 patients were diagnosed by pathogen targeted next-generation sequencing of bronchoalveolar lavage fluid,and TW was the only pathogen in 2 patients.All the 7 patients received antimicrobial therapy,of which 6 patients had significant improvement in clinical symptoms and imaging after treatment,and 1 patient was lost to follow-up.Conclusion Patients with pulmonary TW infection are often accompanied by diseases with abnormal immune function,and it is difficult to be diagnosed by routine laboratory tests,and most of them are diagnosed by next-generation sequencing.Chest CT can show a variety of non-specific changes.Antimicrobial therapy can significantly improve the condition.
万方数据
维普
