Changes of serum regenerative family member 3α and Orai calcium release-activated calcium regulator 1 levels in patients with severe acute pancreatitis complicated with sepsis and their predictive value for prognosis
Objective To investigate the changes of serum regenerative family member 3α(REG3A)and Orai calcium release-activated calcium regulator 1(ORAI1)levels in patients with severe acute pancreatitis(SAP)complicated with sepsis and their predictive value for prognosis.Methods A total of 175 SAP patients complicated with sepsis admitted to Banan Branch of Chongqing University Cancer Hospital from January 2021 to November 2023 were selected as the sepsis group,and 90 SAP patients without sepsis in the same hospital during the same period were selected as the non-sepsis group.The sepsis group was divided into death group and survival group according to the 90-day prognosis.Serum REG3A and ORAI1 levels were detected by enzyme-linked immu-nosorbent assay.Univariate analysis was performed on the death of SAP patients complicated with sepsis,and then multivariate unconditional Logistic regression model was established to analyze the influencing factors with the death of SAP patients complicated with sepsis as the dependent variable.Receiver operating characteristic curve was drawn to evaluate the value of serum REG3A and ORAI1 levels in predicting the death of SAP patients with sepsis.Results No patients dropped out of this study.The levels of serum REG3A and ORAI1 in sepsis group were higher than those in non-sepsis group[(20.3±4.6)μg/L vs(14.4±2.6)μg/L,(39±9)μg/L vs(25±6)μg/L](t=13.457,16.481,both P＜0.001).Univariate analysis showed that the severity of disease,sequential organ failure assessment score,acute physiology and chronic health evaluation Ⅱ score,procalcitonin,REG3 A and ORAI1 were related to the death of SAP patients with sepsis(all P＜0.05).Multivariate unconditional Logistic regression model analysis showed that septic shock,increased sequential organ failure assessment score,increased acute physiology and chronic health evaluation Ⅱ score,increased REG3A and ORAI1 were independent risk factors for death in SAP patients with sepsis(odds ratios=8.105,1.321,1.317,1.540,1.274,all P＜0.05).The area under the curve of serum REG3A combined with ORAI1 for predicting the death of SAP patients with sepsis was 0.893,which was larger than 0.780 and 0.783 of serum REG3A and ORAI1 levels alone(Z=3.990,3.770,both P＜0.001).Conclusion Serum REG3A and ORAI1 levels are increased in SAP patients with sepsis,and these changes are independent risk factors for death.Serum REG3A combined with ORAI1 levels have a high value in predicting the prognosis of SAP patients with sepsis.
Severe acute pancreatitisSepsisRegenerative family member 3αOrai calcium release-activated calcium regulator 1Prognosis
万方数据
维普
