Clinical effect observation of Tongguan Yixin decoction in treating patients with vasospastic angina
Objective To investigate the clinical effect of Tongguan Yixin decoction in the treatment of vasospastic angina(VSA).Methods Totally 96 patients with VSA visited to Hangzhou Traditional Chinese Medicine Hospital,Zhejiang Province from September 2022 to September 2023 were selected and divided into the observation group and the control group adopting a simplified random grouping method,both 48 cases.The control group was treated with western treatment and the observation group was treated with Tongguan Yixin decoction.Both groups were treated for 2 months.During the treatment,2 cases were dropped out of the control group and 2 cases were dropped out of the observation group.Angina pectoris attack,traditional Chinese medicine(TCM)syndrome score,vascular endothelial function,Seattle Angina Pectoris Scale(SAQ)score,myocardial microcircu-lation index(corrected time flow frame count of left circumflex branch,anterior descending branch and right crown)and clinical effect were observed in the two groups before and after treatment.Results After treatment,TCM syndrome score,serum malondialdehyde level,angina pectoris attack frequency,angina pectoris duration,left circumflex branch correction time flow frame count,anterior descending branch correction time flow frame count,right crown correction time flow frame count levels in the two groups were lower/less/shorter than before treatment,and the observation group was lower than the control group(all P＜0.05).After treatment,the levels of serum nitric oxide,superoxide dismutase and SAQ scores in the two groups were higher than those before treatment,and the observation group was higher than the control group(all P＜0.05).After treatment,the total effective rate in the observation group was higher than that in the control group[95.6％(44/46)vs 82.6％(38/46)](P＜0.05).Conclusion Tongguan Yixin decoction can improve vascular endothelial function and myocardial microcirculation in patients with coronary spastic angina.
万方数据
维普
