As the main artery of human blood circulation,the aorta undertakes the key function of trans-porting and distributing the blood pumped by the heart to various organs of the whole body.During blood flow,mechanical stresses are generated in the aorta,mainly including shear stress and mechanical stretch.Physiological mechanical stress maintains the physiological state of blood vessels,while pathological mechanical stress is closely related to the pathological changes of aortic diseases and is one of the risk factors for vascular events.Abnormal mechanical stress disrupts the normal function of endothelial cells and smooth muscle cells through a variety of mechanisms,thereby mediating the initiation and evolution of aortic diseases.This article reviews the latest progress in aortic mechanobiology,aiming to provide new ideas and directions for the prevention and treatment of aortic diseases.
万方数据
维普
