Study on the Anti-rheumatoid Arthritis Effect of Periploca forrestii Schltr.Stem Leaves
Objective:To investigate the effects of Periploca forrestii Schltr.stem leaves on collagen-induced arthritis(CIA)rats model of rheumatoid arthritis(RA),and to explore the potential exploitation of the anti-RA effect of Periploca forrestii Schltr.stem leaves.Methods:Eight SD rats were randomly selected as the normal group,and the remaining rats were established as CIA models.After successful modeling,the rats were randomly divided into model groups,Periploca forrestii Schltr.stem leaves high-dose(100 mg·kg-1)and low-dose(25 mg·kg-1)groups,tripterygium glycosides(TG)(10 mg·kg-1)group,with 8 rats in each group.After the intervention of experimental factors,the AI scores,toe thickness and pathological changes of rats in each group were analyzed and compared.Results:Before and after administration,there was a highly significant difference(P＜0.01)between the normal group and the model group,indicating successful modeling.After administration,measurements of the thickness of the right and left toes of rats showed significant differences(P＜0.05)between the model group and the high and low dose groups of Periploca forrestii Schltr.stem leaves.AI scores showed that there was a significant difference between the high and low dose groups of Periploca forrestii Schltr.stem leaves compared with the model group,and in the intra-group comparison,the swelling reduction effect of the low dose group of Periploca forrestii Schltr.stem leaves was better than that of the high dose group(P＜0.05).The pathological section results showed that a large number of diffuse inflammatory cells infiltrated in the synovial tissue of rats in the model group compared with the normal group.Compared with the model group,the inflammatory cells infiltrated in the synovial tissue of rats in the low-dose group of Periploca forrestii Schltr.stem leaves were reduced.Conclusion:The stem leaves of Periploca forrestii Schltr.have shown good anti-RA effects and have potential value for anti-RA development and utilization.
Periploca forrestii Schltr.stem leavescollagen-induced arthritisrheumatoid arthritisCIA model rats
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万方数据
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