Research Advances in IL-33/ST2 Signaling Pathway and Related Drugs
Objective:To introduce the IL-33/ST2 signaling pathway,its correlation with the occurrence and progression of various diseases,and the development of the corresponding drugs,and to provide ideas for developing new treatment strategies of related diseases.Methods:Through a summary analysis of the available literature on the association between IL-33/ST2 signaling pathway and the pathogenesis of various diseases,the correlation between IL-33/ST2 signaling pathway and diseases and the development of related drugs are discussed and summarized.Results and Conclusion:IL-33 acts as an alarm molecule for immune response and cell damage,and its signaling pathway plays a critical role in the pathogenesis of various diseases such as allergic diseases,chronic inflammation,cancers and cardiovascular diseases.These findings provide new targets and ideas for developing treatment strategies for a variety of diseases.Companies around the world have begun to develop drugs targeting IL-33/ST2 signaling pathway,most of which are monoclonal drugs and have entered different clinical trial stages.These drugs have great application prospect.
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万方数据
维普
