Discovery of Q-markers of Xiebai Powder and Predictive Analysis of Its Mechanism of Action
Objective:To identify Q-markers and predict their mechanisms of action to ensure clinical efficacy.Methods:The quality markers for Xiebai Powder were screened by Q-markers"Five Principles".Databases such as TCMSP and Swiss Target Prediction were used to obtain potential targets of Q-markers,in order to construct a protein interaction network for Q-markers.Through KEGG,GO,and topological enrichment analysis,the"key target-key signal pathway-key biological process"network was constructed to predict the potential mechanism of the Q-markers of Xiebai Powder.Results:This study showed that oxyresveratrol,chlorogenic acid,ferulic acid,liquiritigenin,glycyrrhizic acid and formononetin could be used as potential quality markers of Xiebai Powder.These substances might play a role in regulating the nitric oxide biosynthesis process and AGEs-RAGE signaling pathway in inflammatory response.Conclusion:This article preliminarily explores the quality markers and mechanism of Xiebai Powder,aiming to provide scientific basis for the quality control and clinical application of Xiebai Powder.
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