Preliminary Study on the Anti-cough Active Components of Ligularia hodgsonii Hook.Based on Network Pharmacology
Objective:To obtain the potential active ingredients and protein targets of Ligularia hodgsonii Hook.in the treatment of cough,and to explore the possible mechanism of action by Network Pharmacology.Methods:The chemical constituents of Ligularia hodgsonii Hook.were retrieved from PubMed and other data platforms,then the potential targets screened out through SwissADME and SwissTargetprediction.Cough related targets were obtained by using GeneCards.Key targets were obtained from STRING and Cytoscape,which were used to construct and analyze PPI network.Metascape platform was used for GO biological function process and KEGG metabolic pathway enrichment analysis.Results:Total of 23 key targets was obtained by multi-platform analysis,and most of the corresponding components were eremophilane-type sesquiterpenes.GO analysis obtained biological processes such as positive regulation of protein phosphorylation and regulation of inflammatory response,cellular component such as cell membrane and synapse,molecular function such as protein kinase binding and protein domain specific binding.The results of KEGG enrichment showed the signal pathways related to inflammation.Conclusion:Ligularia hodgsonii Hook.has many active ingredients,which may improve cough symptoms and functions via multi-component multi-target manner and multi-pathway.The underlying mechanism may involve related pathways of inflammation and immunity.
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