Progress in Immunotherapies Targeted to Mesothelin against Solid Tumors
Mesothelin is a tumor associated antigen,a glycoprotein which is highly expressed in over 30％of cancers and only expressed at low levels in a small amount of normal tissues.It is a widely studied cancer immunotherapy target.At present,a variety of immunotherapeutic products targeting mesothelin have shown good safety in clinical researches,especially adoptive cell therapy targeting mesothelin has been developed rapidly in recent years.This article introduces the research progress and trends of solid tumors immunotherapy targeting mesothelin from several aspects,including biological characteristics of mesothelin,clinical trials results of immunotherapy,as well as challenges and response strategies of CAR-T cell immunotherapy.
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