乙型肝炎是由乙型肝炎病毒(Hepatitis B Virus,HBV)感染引起的一种严重危害人类健康的传染病.HBV感染呈世界性流行,造成严重的公共卫生问题.目前,随着疫苗的接种及抗病毒药物的治疗降低了HBV的感染,但HBV的消除仍是一大难题.HBV标志物是诊断HBV感染、观察疾病进展以及评估抗病毒治疗效果的最主要检测指标.临床上,HBV标志物主要包括传统血清学标志物和病毒学标志物以及新型标志物.近年来出现的新型标志物能更准确地评估HBV感染的活性和抗病毒治疗效果,对慢性乙型肝炎的治疗监测具有重要价值.本文就HBV标志物尤其是新型标志物的临床意义及研究进展进行综述,旨在为HBV的精准诊断、治疗以及临床预后等提供参考.
Clinical Significance and Research Progress of Hepatitis B Virus Markers
Hepatitis B is a contagious disease that poses a severe threat to human health,caused by the infection of the Hepatitis B Virus(HBV).HBV infection is a prevalent worldwide,resulting in significant public health issues.Currently,with the administration of vaccines,and the treatment of antiviral drugs,the infection rate of HBV has been reduced.However,the eradication of HBV remains a major challenge.HBV markers are the primary indicators for diagnosing HBV infection,monitoring the progression of the disease,and evaluating the efficacy of antiviral treatment.Clinically,HBV markers mainly include traditional serological markers,virological markers,and new markers.In recent years,new markers have been developed which can more accurately evaluate the activity of HBV infection and the efficacy of antiviral therapy,and are of great value in monitoring the treatment of chronic hepatitis B.In this paper,the clinical significance and research progress of HBV markers,especially new markers,are reviewed,in order to provide references for accurate diagnosis,treatment and clinical prognosis of HBV.
Hepatitis B Virusserological markersvirological markersnew markers
万方数据
维普
