Objective To analyze the correlation of serum C-reactive protein(CRP),B-type brain natriuretic peptide(BNP)and procalcitonin(PCT)between acute lung injury(ALI)and sepsis.Methods All of 53 patients with sepsis admitted to our hospital from January 2019 to December 2022 were selected as the subjects,including 32 patients with concurrent lung injury and 21 patients without concurrent lung injury.Patients with lung injury were divided into low-risk group 15 cases and high-risk group 17 cases according to acute physiology and chronic health status(APACHE Ⅱ)scoring criteria,and were divided into good prognosis 26 cases and poor prognosis 6 cases according to clinical prognosis.The levels of serum CRP,PCT and BNP were determined,and the levels of CRP,BNP,PCT and APACHE Ⅱ scores of each group were compared.The application value of single detection and combined detection in evaluating the prognosis of sepsis and acute lung injury was analyzed.Results CRP(72.98±2.44 vs.15.58±3.21)µg/ml,PCT(4.18±0.16 vs.0.41±0.11)ng/ml,BNP(852.68±51.47)levels in patients with lung injury vs.205.58±45.59)ng/L and APACHE Ⅱ scores(14.98±2.15 vs.8.66±1.12)were higher than those without lung injury(P＜0.05).The levels of CRP(142.65±15.96 vs.68.21±8.45)μg/ml,PCT(10.09±1.33 vs.2.08±0.34)ng/ml and BNP(1 425.52±95.44 vs.796.54±45.59)ng/L were found in high-risk patients and APACHE Ⅱ scores(21.65± 3.01 vs.13.14±1.02)were higher(P＜0.05).The levels of CRP(123.65±5.47 vs.70.58±3.12)μg/ml,PCT(12.18±1.35 vs.4.69±0.84)ng/ml and BNP(1 329.18±91.41 vs.709.54±60.58)ng/L were found in patients with poor prognosis and APACHE Ⅱ scores(19.52±3.97 vs.13.36±3.48)were higher than those of good prognosis(P＜0.05).The diagnostic specificity and sensitivity of combined detection for sepsis and acute lung injury were 77.89％and 83.92％,respectively,and the area under the curve(AUC)was 0.859(95％CI:0.779～0.935),which was higher than that of single detection.Conclusion The severity of acute lung injury and sepsis is detected by serum CRP,BNP and PCT accurately,which has clinical significance for prognosis assessment.
SepsisC-reactive proteinAcute lung injuryProcalcitoninB type brain natriuretic peptide
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